Degree Information:

B.A., University of California, Berkeley, 1990
M.A., Columbia University, 1991
M.Phil., Columbia University, 1994
Ph.D., Columbia University, 1995

Teaches:

Everyday Organic Chemistry (Chem 4)
Everyday Organic Chemistry Lab
An Organic View of the World (Chem 8)
Organic Chemistry I, II, III (Chem 31, Chem 32, Chem 33)
Instrumental Analysis I (Chem 111)
Organic Synthesis (Chem 130, Chem 130 Lab)

Research:

Site-specific attachment of small organic molecules to peptides and proteins, and how the structure and function of the peptides and proteins are altered by the attached molecules.

Active Grants:

“The glycosylation of peptides via hydrazido amino acids and the effect of glycosylation on peptide cleavage by trypsin”, Camille and Henry Dreyfus Foundation, 1999-2004, $20,000

"Combinatorial neoglycopeptide arrays: synthesis and application toward creating bioactive peptides resistant to protolysis", NSF CAREER, 2002-2007, $328,720.

"Synthesis and study of a combinatorial array of neoglycopeptides to determine how glycosylation increases peptide resistance to proteolysis", ACS Petroleum Research Fund, 2001-2003, $25,000.

Recent Publications:

M. R. Carrasco, R. T. Brown, "A Versatile Set of Aminooxy Amino Acids for the Synthesis of Neoglycopeptides", J. Org. Chem. 68, 8853-8858 (2003).

M. R. Carrasco, R. T. Brown, I. M. Serafimova, and O. Silva, "Synthesis of N-Fmoc-O-(N'-Boc-N'-methyl)-aminohomoserine, an amino acid for the facile preparation of neoglycopeptides", J. Org. Chem., 68, 195-197 (2003).

J. C. McNulty, D. A. Thompson, M. R. Carrasco, and G. L. Millhauser, "Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and motions in synthesized peptides and proteins", FEBS Letters, 529, 243-248 (2002).

M. R. Carrasco, M. J. Nguyen, D. R. Burnell, M. D. MacLaren, and S. M. Hengel, "Synthesis of neoglycopeptides by chemoselective reaction of carbohydrates with peptides containing a novel N'-methyl-aminooxy amino acid", Tetrahedron Lett. 43, 5727-5729 (2002).

D. W. Low, M. G. Hill, M. R. Carrasco, S. B. H. Kent, and P. Botti, "Total synthesis of cytochrome b562 by native chemical ligation using a removable auxiliary", Proc. Natl. Acad. Sci. USA 98, 6554-6559 (2001).

P. Botti, M. R. Carrasco, and S. B. H. Kent, "Native chemical ligation using removable Na-1-phenyl-2-mercaptoethyl) auxiliaries", Tetrahedron Lett. 42, 1831-1833 (2001).

Recent Presentations:

M. R. Carrasco, M. J. Nguyen, M. D. MacLaren, D. R. Burnell, and V. A. Sasikumar, "Synthesis of Combinatiorial Neoglycopeptide Arrays", 27th European Peptide Symposium, Sorrento, Italy, 2002.

M. R. Carrasco, M. J. Nguyen, and V. A. Sasikumar, "Synthesis of neoglycopeptides by chemoselective reaction of carbohydrates with peptides containing novel N’-methyl-aminooxy amino acids", 222nd American Chemical Society national meeting, Chicago, IL, August 2001.