Santa Clara University

Biology department

Dr. Amy H. Mooreundefined

Assistant Professor
Alumni Science 360
Santa Clara University
500 El Camino Real
Tel: 408-554-4419
Fax: 408-554-2710
ahmoore@scu.edu

 

 

Educational Background

B.A. 1994 Johns Hopkins University Baltimore, MD
Ph.D. 1999 University of California, Los Angeles Los Angeles, CA
M.A. (Expected 2005) Eastman School of Music,
University of Rochester, Rochester, NY.

Teaching 

Bio 16 Biology of Music
Bio 21 Physiology
Bio 122 Neurobiology

Research

Chronic Neuroinflammation
Neuroinflammation is a prominent feature of brain injury, neural degeneration and aging. My research focuses on the physiological consequences of interleukin-1 infusion in mouse brain, a model for chronic neuroinflammation. Roles for cyclooxgenase, the principal targets of non-steriodal anti-inflammatory drugs (NSAIDs), are also investigated using pharmacological manipulation and genetically-altered animals.

Publications

Moore AH, Olschowka, JA, O'Banion, MK (2004) Intraparenchymal administration of interleukin-1 induces cyclooxygenase-2 (COX-2)-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain, Journal of Neuroimmunology, 148: 32-40.

Moore, AH, Olschowka, JA, Williams, JP, Paige, SL, O'Banion, MK (2004) Radiation-induced edema is dependent on cyclooxygenase-2 activity. Radiation Research. 161(2): 153-160.

Shaftel, SS, Olschowka, JA, Hurley, SD, Moore, AH, O'Banion, MK (2003) COX-3: A splice variant of cyclooxygenase-1 in mouse neural tissue and cells, Molecular Brain Research, 119(2): 213-215.

Ip, EY, Roncat-Zanier, E, Moore, AH, Lee, SM, Hovda, DA (2003) Metabolic, neurochemical, and histological responses to vibrissa motor cortex stimulation following traumatic brain injury: physiological activation as a secondary injury, Journal of Cerebral Blood Flow and Metabolism 23: 900-910.

Moore, AH and O'Banion, MK (2002) Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Advanced Drug Delivery Reviews, 54: 1627-1656.

Kyrkanides, S, Moore, AH, Olschowka, JA, Daeschner,, JC, Williams, JP, Hansen, JT and O'Banion, MK (2002) Cyclooxygenase-2 modulates brain inflammation-related gene expression in CNS radiation injury. Molecular Brain Research 104, 159-169.

Osteen, CL, Moore, AH, Prins, ML and Hovda, DA (2001) Age -dependency of 45calcium accumulation following lateral fluid percussion : Acute and delayed patterns Journal of Neurotrauma 18(2):141-162.

Moore AH, Osteen, CL, Chatziioannou, AF, Hovda, DA, and Cherry, SR. (2000) Quantitative assessment of longitudinal metabolic changes in vivo following traumatic brain injury in adult rat using FDG-microPET. Journal of Cerebral Blood Flow and Metabolism 20:1492-1501.

Chatziioannou, A, Qi, J, Moore, A, Annala, A, Nguyen, K., Leahy, R., Cherry, SR. (2000) Comparison of 3D maximum a posteriori and filtered backprojection algorithms for high resolution animal imaging with microPET. IEEE Transactions in Medical Imaging 19(5):507-512.

Moore, AH, Hovda, DA, Cherry, SR, Villablance, JP, Pollack, DB, and Phelps, ME. (2000) Dynamic changes in cerebral glucose metabolism in conscious infant monkeys during the first year of life as measured by positron emission tomography. Developmental Brain Research 120:141-150.

Moore, AH, Cherry, SR, Pollack, DB, Hovda, DA and Phelps, ME (1999) Application of positron emission tomography to determine cerebral glucose utilization in conscious infant monkeys. Journal of Neuroscience Methods 88: 123-133.

Book Chapters

Samii, A, Moore, AH, Giza, CG, Hovda, DA (2001) Contribution of ionic alterations to metabolic dysfunction following traumatic brain injury. In: Head Trauma: Basic, Preclinical, and Clinical Directions. Editors: Miller, LP and Hayes, RL, John Wiley & Sons, Inc.

Moore, AH, Raleigh, MJ, Cherry, SR, Huang, S-C., and Phelps, ME. (1998) Validation of an [18F]Fluorodeoxyglucose-PET Protocol in Conscious Monkey. In: Quantitative Functional Brain Imaging with Positron Emission Tomography. Editors: Carson, Daube-Witherspoon and Herscovitch, Academic Press.

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