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Personal website: http://webpages.scu.edu/ftp/
B. A., New College of Florida, Chemistry
Biochemistry I (Chem 141) Syllabus
Investigations of the human health and environmental implications of nanoparticles. Specifically, use biochemical and proteomic approaches to understand the interactons of nanoparticles with proteins.
Active Grant:Research Corp for Science Advancement Cottrell College Science Award, "Characterization of the interactions between azurin and silver nanoparticles", $45,000, 2011-2013.
Doku, R.T.; Park, G.*; Wheeler, K.E.; Splan, K.E. Spectroscopic Characterization of Copper(I) Binding to Apo- and Metal-reconstituted Zinc Finger Peptides. Journal of Biological Inorganic Chemistry, 2013, 1-10. DOI: 10.1007/s00775-013-1012-6
Martinolich, A.J.;* Park, G.;* Nakamoto, M.Y.;* Gate, R.E.;* Wheeler, K.E. Differential impact of silver nanoparticles and their dissolution ions on metalloprotein function. Environmental Science and Technology, 2012, 46 (11), 6355–6362.
Wheeler, K.E.; Erickson, B.K.; Mueller, R.; Singer, S.W.; VerBerkmoes, N.C.; Hwang, M.; Thelen, M.P.; and Hettich, R.L. Metal Affinity enrichment increases the range and depth of proteome identification for extracellular microbial proteins Journal of Proteomics Research 2012, 11 (2), 861‐70.
Goltsman, D.S.; Denef, V.J.; Singer, S.W.; VerBerkmoes, N.C.; Lefsrud, M.; Muller, R.; Wheeler, K.E.; Zemla, A.; Dick, G.J.; Hauser, L.; Land, M.; Shah, M.; Thelen, M.P. Hettich, R.L.; Banfield, J.F. “Comparative proteogenomic analyses of biofilm communities dominated by chemoautotrophic, iron-oxidizing ‘Leptospirillum rubarum’ and Leptospirillum ferrodiazophum populations” Applied and Environmental Microbiology (2009), 02943-08v1 .
Wheeler, K.E.; Cull, D.A.; Nocek, J.M.; Yatsunyak, L.; Rosenzweig, A.C.; Hoffman, B.M. “Dynamic Docking of Cytochrome b5 with Myoglobin and α-Hemoglobin: Heme Neutralization ‘Squares’ and the Properties of the Electron-Transfer-Reactive Configurations”, Journal of the American Chemical Society (2007), 129(13):3906-17.
Wheeler, K.E.; Nocek, J.M.; Hoffman, B.M. “NMR Spectroscopy Can Characterize Proteins Encapsulated in a Sol-Gel Matrix”, Journal of the American Chemical Society (2006), 128(46):14782-3.
A brief interview with Dr. Wheeler:
Initially I was drawn to SCU by the strong, hardworking student body. It was encouraging to see a true community based on both student and faculty development and learning. The commitment to a diverse learning experience was evidenced by the strong research and student involvement in programs outside of the classroom.
I find a ridiculous amount of joy in the simplicity of understanding a protein’s structure and function. More specifically, I’ve had a long interest in the role of metals in biology; one metal atom can make such a huge difference in a protein’s function. In fact, my first undergraduate research project was in bioinorganic chemistry - one reason I believe so strongly in undergraduate research.
I have delighted in watching the field of nanoscience progress, from novel approaches to manipulate and view tiny molecular structures to the more recent application-based technologies. In addition, the latest discoveries in the field of epigenetics are very exciting. Epigenetics is the study of heritable changes in gene function and expression without changing a gene’s sequence - a whole new layer to understanding nature verses nurture!