Santa Clara University

bioengineering

Course Descriptions

Lower-Division Courses

BIOE 10. Introduction to Bioengineering
An introduction to the central topics of bioengineering, including the application of engineering methods and science to problems in biology and medicine, and the integration of engineering and biology. Current issues and opportunities in the field will be discussed. Course may include lectures, class discussions, guest lectures, field trips, short lab exercises, and team projects. (4 units)

BIOE 21. Introduction to Physiology
This course will cover five anatomical systems and how the structure of the human body relates to and defines its function in maintaining homeostasis. This course will introduce cytology, histology and also focus on diseases related to the skeletal, nervous, sensory, muscular, endocrine, and reproductive systems. (4 units)

BIOE 22. Introduction to Cell and Molecular Bioengineering
The aim of this course is to introduce students to fundamental concepts in cell and molecular biology. Topics covered in the course will include cellular structure and function, biological molecules, molecular mechanism of cellular function, cell proliferation and signaling. This course will also emphasize the importance of applications of genetic engineering in human health and diseases. Course will include lectures, peer reviewed papers, class discussion, short lab exercises, and team projects. Prerequisite: BIOE 21. (4 units)

BIOE 22L. Laboratory for BIOE 22
Co-requisite: BIOE 22. (1 unit)

Upper-Division Courses 

BIOE 100. Bioengineering Research Seminar
A series of one-hour seminars will be presented by guest professors and researchers on their particular research topics in bioengineering or related fields. Students are required to attend four to five seminars and submit a one-page report summarizing the presentation for each seminar. May be repeated for credits. Prerequisite: Sophomore standing or higher. P/NP grading. (1 unit)

BIOE 107. Medical Device Product Development
The purpose of this course is to provide background information and knowledge to start or enhance a career in medical device product development. Discusses medical device examples, product development processes, regulation, industry information, and intellectual property. Also listed as EMGT 307. Prerequisite: BIOE 10. (2 units)
 
BIOE 108. Biomedical Devices: Role of Polymers
This course is designed to highlight the role polymers play in the design and fabrication of various medical devices ranging from simple intravenous drip systems to complex cardiac defibrillator implants and transcatheter heart valves. Topics include polymer basics, biocompatibility, biodegradation and other tangentially related topics such as regulatory body approvals and intellectual property. Also listed as BIOE 208. (2 units)
 
BIOE 120. Experimental Methods in Bioengineering
This course will cover the principles of data representation, analysis, and experimental designs in bioreactors, biomaterials, and medical devices. Topics include error analyses, modeling, Normality testing, hypothesis testing, and design of experiments. Special emphases will be placed on the interpretation of data from high-throughput assays used in "omics"/ tissue engineering, and formulation designs used for optimal drug delivery. Prerequisite: MATH 14. (4 units)
 
BIOE 140. Biomaterials Engineering and Characterization
This course will cover the fundamental principles of soft biomaterials characterization in terms of mechanical and rheological properties related to biocompatibility. Areas of focus in the lab include study and fabrication of implantable hydrogels for eukaryotic cell immobilization in scaffolds and microcapsules, cytotoxicity measurements in the engineered micro-environment and nutrient diffusion visualized by fluorescence microscopy. Also listed as BIOE 240. Prerequisite: CHEM 13. (2 units)
 
BIOE 140L. Laboratory for BIOE 140
Also listed as BIOE 240L. Co-requisite: BIOE 140. (1 unit)
 
BIOE 153. Biomaterials Science
An introduction into materials used for medical devices. Focus areas include materials science, biology, biochemistry, practical aspects of biomaterials, industry literature, and applications. Prerequisite: CHEM 13. (4 units)
 
BIOE 154. Introduction to Biomechanics
Engineering mechanics and applications in the analysis of human body movement, function, and injury. Review of issues related to designing devices for use in, or around, the human body including safety, biocompatibility, ethics, and Food and Drug Administration (FDA) regulations. Prerequisites: BIOE 10, PHYS 33. (4 units)
 
BIOE 155. Biological Transport Phenomena
The transport of mass, momentum, and energy are critical to the function of living systems and the design of medical devices. This course develops and applies scaling laws and the methods of continuum mechanics to biological transport phenomena over a range of length and time scales. Prerequisites: BIOE 10, PHYS 33, AMTH 106. (4 units)
 
BIOE 157. Introduction to Biofuel Engineering
This course will cover the basic principles used to classify and evaluate biofuels In terms of thermodynamic and economic efficiencies as well as environmental impact for resource recovery. Special emphases will be placed on emerging applications namely Microbial Fuel Cell Technology and Photo-bioreactors. Also listed as BIOE 257/ENGR 257. (2 units)
 
BIOE 161. Bioinstrumentation
Transducers and biosensors from traditional to nanotechnology; bioelectronics and measurement system design; interface between biological system and instrumentation; data analysis; clinical safety. Laboratory component will include traditional clinical measurements and design and test of a measurement system with appropriate transducers. Also listed as ELEN 161. Prerequisites: BIOE 10, BIOE 21 (or BIOL 21), ELEN 50. (4 units)
 
BIOE 161L. Laboratory for BIOE 161
Co-requisite: BIOE 161. (1 unit)
 
BIOE 162. BioSignals and Systems
Origin and characteristics of bioelectric, bio-optical, and bioacoustic signals generated from biological systems. Behavior and response of biological systems to stimulation. Acquisition and interpretation of signals. Signal processing methods include FFT spectral analysis and time-frequency analysis. Laboratory component will include modeling of signal generation and analysis of signals such as electrocardiogram (ECG), electromyogram (EMG), and vocal sound pressure waveforms. Also listed as ELEN 162. Prerequisites: BIOE 10, AMTH 106. (4 units)
 
BIOE 162L. Laboratory for BIOE 162
Co-requisite: BIOE 162. (1 unit)
 
BIOE 163. Bio-Device Engineering
This course will instruct students with the fundamental principles of bio-device design, fabrication and biocompatibility, and let students experiment with the state-of-the-art bio-devices. Students will gain the hands-on experience with these bio-instruments which are also used in the field. Emphasis is given to the cutting-edge applications in biomedical diagnostics and pharmaceutical drug discovery and development, particularly detection and monitoring interaction, and activity of biomolecules, such as enzymes, receptors, antibody, nucleic acids, and bioanalytes. Prerequisites: BIOL 25 or BIOE 22 & CHEM 31. (4 units)
 
BIOE 163L. Laboratory for BIOE 163
Co-requisite: BIOE 163. (1 unit)
 
BIOE 167. Medical Imaging Systems
Overview of medical imaging systems including sensors and electrical interfaces for date acquisition, mathematical models of the relationship of structural and physiological information to senor measurements, resolution and accuracy limits based on the acquisition system parameters, impact of the imaging system on the volume being imaged, data measured, and conversion process from electronic signals to image synthesis. Analysis of the specification and interaction of the functional units of imaging systems and the expected performance. Focus on MRI, CT, ultrasound, PET, and impedance imaging. Also listed as ELEN 167. Prerequisites: BIOE 162/ELEN 162 or ELEN 110 or MECH 142. (4 units)
 
BIOE 168. Biophotonics and Bioimaging
This course focuses on the interactions of light with biological matter and included topics on the absorption of light by biomolecules, cells and tissues, and emission of light from these molecules via fluorescence and phosphorescence. The course will cover the application of biophotonics in cell biology, biotechnology, and biomedical imaging. Also listed as BIOE 268. Prerequisites: BIOE 10 and PHYS 33. (2 units)
 
BIOE 171. Physiology and Anatomy for Engineers
Examines the structure and function of the human body and the mechanisms for maintaining homeostasis. The course will provide a molecular-level understanding of human anatomy and physiology in select organ systems. The course will include lectures, class discussions, case studies, computer simulations, field trips, lab exercises, and team projects. Prerequisite: BIOE 21 or BIOL 21. (4 units)
 
BIOE 171L. Laboratory for BIOE 171
Co-requisite: BIOE 171. (1 unit)
 
BIOE 172. Tissue Engineering I
Introduces the basic principles underlying the design and engineering of functional biological substitutes to restore tissue function. Cell sourcing, manipulation of cell fate, biomaterial properties and cell-material interactions, and specific biochemical and biophysical cues presented by the extracellular matrix will be discussed, as well as the current status and future possibilities in the development of biological substitutes for various tissue types. Prerequisite: BIOE 22 or BIOL 25. (4 units)
 
BIOE 172L. Laboratory for BIOE 172
Co-requisite: BIOE 172. (1 unit)
 
BIOE 173. Tissue Engineering II
This course will provide a detailed overview of the progress achieved in developing tissue engineering therapies for a wide variety of human diseases and disorders. It will organized into two sections; the first section will provide a basic overview of in vivo tissue growth and development, tools and materials needed to design tissues and organs, stem cell biology and other emerging technologies. This basic section will be complemented by a series of recent examples in applying tissue engineering to various organ systems. Prerequisite: BIOE 172. (4 units)
 
BIOE 174. Microfabrication and Microfluidics for Bioengineering Applications
Focuses on those aspects of micro/nanofabrication that are best suited to BioMEMS and microfluidics to better understand and manipulate biological molecules and cells. The course aims to introduce students to the state-of-art applications in biological and biomedical research through lectures and discussion of current literature. A team design project that stresses interdisciplinary communication and problem solving is one of the course requirements. Prerequisites: BIOE 10, BIOE 21 or BIOL 21. (4 units)
 
BIOE 175. Biomolecular and Cellular Engineering I
This course will focus on solving problems encountered in the design and manufacturing of biopharmaceutical products, including antibiotics, antibodies, protein drugs and molecular biosensors, with particular emphasis on the principle and application of protein engineering and reprogramming cellular metabolic networks. Prerequisites: BIOL 25 or BIOE 22 & CHEM 31, or equivalent knowledge and by instructor's permission. BIOE 153 is recommended. (4-units)
 
BIOE 175L. Laboratory for BIOE 175
Co-requisite: BIOE 175. (1 unit)
 
BIOE 176. Biomolecular and Cellular Engineering II
This course will focus on the principle of designing, manufacturing synthetic materials and their biomedical and pharmaceutical applications. Emphasis of this class will be given to chemically synthetic materials, such as polymers, inorganic and organic compounds. Prerequisites: BIOL 25 or BIOE 22 & CHEM 31, or equivalent knowledge and by instructor's permission. BIOE 175 and BIOE 171 recommended. (4 units)
 
BIOE 177L. Advanced Molecular Bioengineering Lab
This course is the lab session of BIOE 176. Lab sections are designed for students to experience the concepts of bioprocess engineering and biochemical engineering. Prerequisite: BIOE 176. (1 unit)
  
BIOE 178. Clinical Biomaterials
The objective of this course is to convey the state-of-the-art of biomaterials currently used in medical devices. The course is taught as a series of semi-independent modules on each class of biomaterial, each with examples of medical applications. Students will explore the research, commercial and regulatory literature. In teams of 2 to 4, students will prepare and orally present a design study for a solution to a medical problem requiring one or more biomaterials, covering alternatives and selection criteria, manufacture and use of the proposed medical device, and economic, regulatory, legal and ethical aspects. Students should be familiar with or prepared to learn medical, anatomical and physiological terminology. Written assignments are an annotated bibliography on the topic of the design study and an individually written section of the team's report. Material from lectures and student presentations will be covered on a mid-term quiz and a final examination. Also listed as BIOE 278 and MECH 256. Prerequisite: BIOE 153 (or with consent of the instructor). (2 units)
 
BIOE 179. Physiology and Disease Biology I
The course will provide a molecular-level understanding of human physiology and disease biology, an overview of cardiovascular disease, diagnostic methods, and treatment strategies. Engineering principles to evaluate the performance of cardiovascular devices and the efficacy of treatment strategies will also be discussed. The course will include lectures, class discussions, case studies, and team projects. Also listed as BIOE 275. Prerequisites: BIOE 21 and BIOE 22 or BIOL 21, BIOL 24 & BIOL 25. (2 units)
 
BIOE 180. Clinical Trials: Design, Analysis and Ethical Issues
This course will cover the principles behind the logistics of design and analysis of clinical trials from the statistical and ethical perspectives. Topics include methods used for quantification of treatment effect(s) and associated bias interpretation, cross-over designs used in randomized clinical trials and clinical equipoise. Prerequisites: BIOE 10, AMTH 108 or BIOE 120 (or with consent of the instructor). (4 units)
 
BIOE 185. Physiology and Disease Biology II
The course will provide a molecular-level understanding of physiology and disease biology, an overview of gastrointestinal diseases, and an introduction to medical devices used in the diagnosis and treatment as well as challenges in this field. The course will include lectures, class discussions, case studies, and team projects. Also listed as BIOE 285. (2 units)
 
BIOE 186. Current and Emerging Techniques in Molecular Bioengineering
The course is designed to introduce basic and practical biotechniques to students with minimum training and background in biomolecular engineering. The basic principles and concepts of modern biotechniques will be illustrated and highlighted by studying real cases in lectures. Prerequisite: BIOE 22 or BIOL 24. (2 units)
 
BIOE 192. Junior Design
Establishes a foundation for the Senior Design sequence. Students will be given a broad overview of the possible project offerings and will be directed to meet potential project advisors to learn more about their research and previous senior design projects. As a part of this course, students will also be introduced to the necessary 'soft skills,' (e.g. literature review, documentation, market research, experimental design, etc.) as they develop feasible senior design concepts. Prerequisite: Junior standing. P/NP grading. (1 unit)
 
BIOE 194. Design Project I
Specification of an engineering project, selected with the mutual agreement of the student and the project advisor. Complete initial design with sufficient detail to estimate the effectiveness of the project. Initial draft of the project report. Prerequisite: Senior standing. (2 units)
 
BIOE 195. Design Project II
Continued design and construction of the project, system, or device. Second draft of project report. Prerequisite: BIOE 194. (2 units)
 
BIOE 196. Design Project III
Continued design and construction of the project, system, or device. Final report. Prerequisite: BIOE 195. (2 units)
 
BIOE 198. Internship
Directed internship in local bioengineering and biotech companies or research in off-campus programs under the guidance of research scientists or faculty advisors. Required to submit a professional research report. Open to upper-division students. (Variable units)
 
BIOE 199. Supervised Independent Research
By arrangement. Faculty advisor required. (1–4 units)