Session 1, Abstract 4

COMPARATIVE GENOMICS OF ​STREPTOMYCES AUREOFACIENS ​AND CLOSELY RELATED BACTERIAL SPECIES

Nick Johnson*, Julien S. Gradnigo and Etsuko N. Moriyama (Jerald Bricker), Biology Department, Nebraska Wesleyan University, Lincoln, NE, School of Biological Sciences, Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68508

Streptomyces aureofaciens is used in industry to produce antibiotics. Although it has been the subject of many biochemical studies, not much is known about its evolutionary relationships among other Streptomyces and related species. We compared the new assembly of the S. aureofaciens ATCC 10762 genome against more than 20 other Streptomyces and closely related bacterial genomes. We identified 183 genes (e.g., 16S rRNA, recA) that are conserved among these genomes. Our phylogenomic analysis showed that the S. aureofaciens ATCC 10762 genome was significantly closer to Kitasatospora genomes than other Streptomyces genomes. Comparative genomic analyses reveal that S. aureofaciens strains NRRL B-2657, NRRL 2209 and NRRL B-1286 are most closely related to the type strain ATCC 10762, while strains NRRL B-2658 and NRRL B-2183 appear significantly divergent.

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