Session 4, Abstract 21

WHOLE-BODY MATHEMATICAL MODELS OF SYNTHETIC BIOSENSING LIPOSOMES

Tanishq Abraham* (Cheemeng Tan), University of California Davis, Department of Biomedical Engineering, College of Engineering, 2063 Bioletti Way, Davis, CA 95616

Liposomes are commonly used as drug delivery systems for therapeutic treatment. To maximize the efficiency of drug delivery, it is important to tune the physicochemical parameters of liposomes to optimize the bioavailability of the encapsulated drug. Along this line, mathematical models are commonly used in a priori modeling and design of liposomes. However, whole-body pharmacokinetic models for liposome is currently lacking due to focus of only accumulation in tumor. However, that is not the only use for liposomes in vivo. Here, we formulate a universal whole-body physiologically-based pharmacokinetic model (WPBPK) for various liposome sizes and transport processes using a blood-flow-limited and permeability-limited model. The permeability-limited model simulates nonlinear diffusion and convection, which also considers the effect of various liposome sizes and microvascular physiologies. The model will be validated with in vivo results from the literature. This work is important for mathematical modeling of liposome bioavailability a priori, especially for other uses apart from tumor drug delivery. This also provides a platform to develop a model for circulating liposomes from experimental data.

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