Session 7, Abstract 44
EFFECTS OF PHTHALATE PLASTICIZERS ON XENOPUS DEVELOPMENT
Cooper Maloney* (Sonya Schuh), Saint Mary's College of California.
The presence of environmental toxins in plastics has become a topic of large debate as such plasticizers have been known to cause detrimental effects to animals, plants, and the environment. In this research study, phthalate plasticizers common in plastics such as polyvinyl chloride (PVC) were investigated for their effects on Xenopus laevis embryonic development. These compounds have been found to cause developmental and hormonal abnormalities in various species due to their estrogenic qualities. The effects of the common type, di-n-butyl phthalate (DBP) on the early development of X. laevis was observed at exposures of 1 µM and 25 µM and 200 µM. 0.1X MMR was used as a solvent for one experiment and DMSO and 0.1X MMR as the solvents for the second experiment. Results showed abnormalities to be more prevalent in the embryos exposed to higher concentrations of DBP; specifically, deformities arose at many different development stages most often causing an enlarged gut and/ or hindered axis elongation. More studies are needed to support this evidence and specify the exact stage and structure of which the chemical effects.