Le's primary teaching area is global business with interests in design thinking, global citizenship, social entrepreneurship, and spiritual leadership. His research interests include microfinance, Jesuit business education, global Asian migration diasporas, the political economy of development in frontier markets, and state-owned enterprises in Asia.

He is also a practitioner of microfinance in which he and his students founded Zero Interest Microfinance Bank, providing zero-interest lending and business education to small and medium-sized enterprises around the world.

Prior to Santa Clara University, Le was a clinical professor and director of International Initiatives for Global Studies at the C.T. Bauer School of Business at the University of Houston. He was also a visiting researcher at the International Islamic University of Malaysia and a research fellow at the City University of Hong Kong.

Le received his bachelor of arts degree from the University of Delaware, and his Ph.D. from the University of Houston.