Ian Carter-O'Connell
Ph.D. Biochemistry, Harvard University
B.A. Biochemistry, The Colorado College
In the Carter-O'Connell lab we are focused on using biochemistry to uncover the role of ADP-ribosylation in both normal human physiology (cell development, signal transduction, gene regulation) and disease (such as cancer). We aim to couple a deeper understanding of the fundamental principles that govern ADP-ribose transfer in the cell to the biological outcomes of normal and malignant ADP-ribose signaling.
- Biochemistry I (Chem 141)
- Biochemistry Lab (Chem 143)
Javed, Z.*, Nguyen, H.H.*, Harker, K.K.*, Mohr, C.M.*, Vano, P.*, Wallace, S.R.*, Silvers, C.*, Sim, C.*, Turumella, S.*, Flinn, A.*, Moritz, A.*, and Carter-O'Connell, I. "Using TLC-MALDI-TOF to Interrogate In Vitro Peptidyl Proximal Preferences of PARP14 and Glycohydrolase Specificity" Molecules 2023, 28 (16): 6061. https://doi.org/10.3390/molecules28166061
Wallace, S.R.*; Chihab, L. Y.*; Yamasaki, M.*; Yoshinaga, B.T.*; Torres, Y. M.*; Rideaux, D.*; Javed, Z.*; Turumella, S.*; Zhang, M.*; Lawton, D.R.*; Fuller, A.A.; Carter-O’Connell, I. Rapid Analysis of ADP-Ribosylation Dynamics and Site-Specificity Using TLC-MALDI. ACS Chem. Biol. 2021, 16, 2137-2143. doi: 10.1021/acschembio.1c00542
Carter-O’Connell, I.; Vermehren-Schmaedick, A.; Jin, H.; Morgan, R.K.; David, L.L.; Cohen, M.S. Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14). ACS Chemical Biology 2018, 13, 2841-2848.
Carter-O’Connell, I., Jin, H., Morgan, R.K., Zaja, R., David, L.L., Ahel, I., and Cohen, M.S. (2016). Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach. Cell Reports. 14(3): 621-31.
Morgan, R.K., Carter-O’Connell, I., and Cohen, M.S. (2015). Selective Inhibition of PARP10 Using a Chemical Genetics Strategy. Bioorganic and Medicinal Chemistry Letters. 25(21): 4770-3.
Carter-O’Connell, I. and Cohen, M.S. (2015). Identifying Direct Protein Targets of Poly-ADP-Ribose Polymerases (PARPs) Using Engineered PARP Variants-Orthogonal Nicotinamide Adenine Dinucleotide (NAD+) Analog Pairs. Current Protocols in Chemical Biology. 7(2): 121-39.
Carter-O’Connell, I., Jin H., Morgan, R.K., David, L.L., and Cohen, M.S. (2014). Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets. Journal of the American Chemical Society. 136(14): 5201-4.
Carter-O’Connell, I., Peel, M., Wykoff, D.D., and O’Shea, E.K. (2012). Genome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe. BMC Genomics. 13:697.
Carter-O’Connell, I., Booth, D., Eason, B., and Grover, N.K. (2008). Thermodynamic Examination of Trinucleotide Bulged RNA in the Context of HIV-1 TAR RNA. RNA. 14(12): 2550-6.