Investigations of the environmental and human health implications of Nanomaterials. Specifically, use biochemical and proteomic approaches to understand the interactions of nanoparticles with biomolecules.
University of California Center for the Environmental Implications of Nanotechnology, SEED grant sub-award from the National Science Foundation, 2014-2015
Research Corp for Science Advancement Cottrell College Science Award, 2011-2013.
Advanced Biosciences Initiative, W. F. Keck Foundation, 2011-2013
Recent Publications (SCU undergraduate co-authors annotated with an asterisk,*)
Freitas, D.N.*, Martinolich, A.J.*,Amaris, Z.N.*, Wheeler.K.E. "Beyond the passive interactions at the Nano-Bio interface: Evidence of Cu metalloprotein driven oxidative dissolution of silver nanoparticles" Journal of Nanobiotechnology, 2016, 14:7. DOI: 10.1186/s12951-016-0160-6.
Eigenheer, R., Castellanos, E.R.*, Nakamoto, M.Y.*, Gerner, K.T.*, Lampe, A.M.* Wheeler, K.E. Silver .Nanoparticle Protein Corona Composition Compared Across Engineered Particle Properties and Environmentally Relevant Reaction Conditions. Environmental Science: Nano,2014, 1(3), 238-247 Featured on the back, front cover and highlighted as a "HOT article" by the journal.
Doku, R.T.; Park, G.*; Wheeler, K.E.; Splan, K.E. Spectroscopic Characterization of Copper(I) Binding to Apo- and Metal-reconstituted Zinc Finger Peptides. Journal of Biological Inorganic Chemistry,2013, 1-10.DOI: 10.1007/s00775-013-1012-6
Martinolich, A.J.;* Park, G.;* Nakamoto, M.Y.;* Gate, R.E.;* Wheeler, K.E. Differential impact of silver nanoparticles and their dissolution ions on metalloprotein function. Environmental Science and Technology, 2012, 46 (11), 6355–6362.
Freitas, DN; Martinolich, AJ; Amaris, ZN; Wheeler, KE “Beyond the Passive Interactions at the Nano-bio Interface: Evidence of Cu Metalloprotein-driven Oxidation Dissolution of Silver Nanoparticles” Journal of Nanobiotechnology2016, 14, 7.