My research is focused on understanding the physiological processes by which neural activity produces behavior, and more specifically, how dysfunctional neural circuitry leads to aberrant behavior. I am particularly interested in the overlap between reward and aversion circuits and currently am researching the long-term effects of early life stress on social behavior, reward processing, and aversive memory formation.
PSYC 1: General Psychology I
PSYC 65: Foundations of Behavioral Neuroscience
PSYC 165: Behavioral Neuroscience
PSYC 168: Advanced Topics in Neuroscience
NEUR 10: Explorations in Neuroscience
NEUR 190: Neuroscience Capstone1
Henderson HJM, Etem G, Bjorni M, Belnap MA, Rosellini B, Halladay LR (2021). Sex-dependent and ontogenetic effects of low dose ethanol on social behavioral deficits induced by mouse maternal separation. Behavioural Brain Research.
Piantadosi P, Halladay LR, Radke AK, Holmes A (2021). Advances in understandingmeso-cortico-limbic-striatal systems mediating risky reward seeking. Journal of Neurochemistry.
Glover LR, McFadden KM, Bjorni M, Smith SR, Rovero NG, Oreizi-Esfahani S, Yoshida T, Postle AF, Nonaka M, Halladay LR, Holmes A (2020). A prefrontal-bed nucleus of thestria terminalis circuit limits fear to uncertain threat. eLife.
Emmons R, Sadok T, Rovero NG, Belnap MA, Henderson HJM, Quan AJ, Del Toro NJ, Halladay LR (2020). Chemogenetic manipulation of the bed nucleus of the stria terminalis counteracts social behavioral deficits induced by early life stress in C57BL/6J mice. Journal of Neuroscience Research.
Halladay LR, Kocharian A, Piantadosi PT, Authement M, Lieberman AG, Spitz NA, Coden K, Glover L, Costa VD, Alvarez VA, Holmes A (2020). Prefrontal regulation of punished ethanol self-administration. Biological Psychiatry, 87:967-78.
Bjorni M, Rovero NG, Yang ER, Holmes A, Halladay LR (2020). Phasic signaling in the bed nucleus of the stria terminalis during fear learning predicts within- and across-session cued fear expression. Learning and Memory 27:83-90.
Hardaway JA, Halladay LR, Mazzone CM, Pati D, Bloodgood DW, Kim M, Jensen J, DiBerto JF, Boyt KM, Shiddapur A, Erfani A, Hon OJ, Neira S, Stanhope CM, Sugam JA, Saddoris MP, Tipton G, McElligott Z, Jhou TC, Stuber GD, Bruchas MR, Bulik CM, Holmes A, Kash TL (2019) Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron.
Gunduz-Cinar O, Brockway E, Lederle L, Wilcox T, Halladay LR, Ding Y, Oh H, Busch EF, Kaugars K, Flynn S, Limoges A, Bukalo O, MacPherson KP, Masneuf S, Pinard C, Sibille E, Chesler EJ, Holmes A (2019). Identification of a novel gene regulating amygdala-mediated fear extinction. Molecular Psychiatry24(4):601-612.
Halladay LR, Kocharian A, Holmes A (2017) Inter-strain variation in mouse compulsive-like ethanol self-administration. Alcohol 58:83-92.
Marcinkiewcz CA, Mazzone CM, D’Agostino GD, Halladay LR, Hardaway A, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton G, Ramakrishnan C, Kozicz T, Deisseroth K, Thiele T, McElligott ZA, Holmes A, Heisler LK, Kash TL (2016) Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature 537:97-101.
Knoll A, Halladay LR, Holmes A, Levitt P (2016). Quantitative trait loci and a novel genetic candidate for fear learning. Journal of Neuroscience 36:6258-68.
Gamble-George J, Baldi R, Halladay L, Money K, Kocharian A, DeSilva C, Roberts H, Haymer A, Marnett LJ, Mirnics K, Holmes A, Patel S (2016). Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. eLife 5:e14137.
Halladay LR, Blair HT (2016). Prefrontal infralimbic cortex mediates competition between excitation and inhibition of body movements during pavlovian fear conditioning. Journal of Neuroscience Research (ePub ahead of print).
(Invited manuscript, Special Issue: Corticoamygdala Circuits in Health and Disease)
Hartley N, Gunduz-Cinar O, Halladay L, Bukalo O, Holmes A, Patel S (2016). 2-Arachidonoylglycerol signaling impairs short-term fear extinction. Translational Psychiatry 6:e749.
Runco MA, Acar S, Kaufman JC, Halladay LR (2016). Changes in Reputation and Associations with Fame and Biographical data. Journal of Genius and Eminence 1:52-60.
Halladay LR, Blair HT (2015). Distinct ensembles of medial prefrontal cortex neurons are activated by threatening stimuli that elicit excitation versus inhibition of movement. Journal of Neurophysiology 114:793-807.
Kiselycznyk C, Jury NJ, Halladay LR, Nakazawa K, Mishina M, Sprengel R, Grant SG, Svenningsson P, Holmes A (2015). NMDA receptor subunits and associated signaling molecules mediating the antidepressant-related effects of NMDA-GluN2B antagonism. Behavioral Brain Research 287:89-95.
Halladay LR, Blair HT (2012). The role of mu-opioid receptor signaling in the dorsolateral periaqueductal gray on conditional and unconditional responding to threatening and aversive stimuli. Neuroscience 216:82-93.
Halladay LR, Zelikowsky M, Blair HT, Fanselow MS (2012). Reinstatement of extinguished fear by an unextinguished conditional stimulus. Frontiers in Behavioral Neuroscience 6:18.
Tarpley JW, Shlifer IG, Halladay LR, Blair HT (2010). Conditioned turning behavior: A Pavlovian fear response expressed during the post-encounter period following aversive stimulation. Neuroscience 169:1689-704.
Runco MA, Kaufman JC, Halladay LR, Cole JC (2010). Change in reputation as an index of genius and eminence. Historical Methods 43:91-96.
Tarpley JW, Shlifer IG, Birnbaum MS, Halladay LR, Blair HT (2009). Bilateral phosphorlyation of ERK in the lateral and centrolateral amygdala during unilateral storage of fear memories. Neuroscience 164:908-17.
Halladay LR, Iñiguez SD, Furqan F, Previte M, Chisum AM, Crawford CA (2009). Methylphenidate potentiates morphine-induced antinociception, hyperthermia, and locomotor activity in young adult rats. Pharmacology, Biochemistry, and Behavior 92:190-6.
Charntikov S, Halladay LR, Herbert MS, Marquez EM, McDougall SA (2008). Effects of dorsal striatal infusions of R(-)-propylnorapomorphine (NPA) on k-opioid-mediated locomotor activity in the young rat: possible role of the indirect pathway. Neuroscience 155:603-12.
McDougall SA, Baella SA, Stuebner NM, Halladay LR, Crawford CA (2007). Cocaine-induced behavioral sensitization in preweanling and adult rats: effects of a single drug-environment pairing. Psychopharmacology (Berl). 193:323-32.