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Department ofBioengineering

Course Descriptions

10. Introduction to Bioengineering

An introduction to the central topics of bioengineering, including the application of engineering methods and science to problems in biology and medicine, and the integration of engineering and biology. Current issues and opportunities in the field will be discussed. Course may include lectures, class discussions, guest lectures, field trips, short lab exercises, and team projects. (4 units)

21. Introduction to Physiology

This course will cover five anatomical systems and how the structure of the human body relates to and defines its function in maintaining homeostasis. This course will introduce cytology, histology, and also focus on diseases related to the skeletal, nervous, sensory, muscular, endocrine, and reproductive systems. (4 units)

22. Introduction to Cell and Molecular Bioengineering

The aim of this course is to introduce students to fundamental concepts in cell and molecular biology. Topics covered in the course will include cellular structure and function, biological molecules, molecular mechanism of cellular function, cell proliferation and signaling. This course will also emphasize the importance of applications of genetic engineering in human health and diseases. Course will include lectures, peer reviewed papers, class discussion, short lab exercises, and team projects. Prerequisite: BIOE 21 or BIOL 1B. Co-requisite: BIOE 22L. (4 units)

22L. Introduction to Cell and Molecular Bioengineering Laboratory

Laboratory for BIOE 22. Co-requisite: BIOE 22. (1 unit)

100. Bioengineering Research Seminar

A series of one-hour seminars will be presented by guest professors and researchers on their particular research topics in bioengineering or related fields. Students are required to attend four to five seminars and submit a one-page report summarizing the presentation for each seminar. May be repeated for credits. P/NP grading. Also listed as BIOE 200. (1 unit)

106. Design Control for Medical Devices

This course will the cover the principles behind design control. All of the essential elements required in the regulated medical device environment will be covered from design planning, inputs and outputs to verification, validation, risk management and design transfer. A problem-based learning approach will be utilized so that students will develop proficiency to apply the principles. Knowledge will be acquired through lectures, class activities, industry guest lectures and field trips. Also listed as BIOE 206. (2 units)

107. Medical Device Invention - From Ideas to Business Plan

This course will introduce students to various tools and processes that will improve their ability to identify and prioritize clinical needs, select the best medical device concepts that address those needs, and create a plan to implement inventions. Also listed as BIOE 207. (2 units)

108. Biomedical Devices: Role of Polymers

This course is designed to highlight the role that polymers play in the design and fabrication of various medical devices ranging from simple intravenous drip systems to complex cardiac defibrillator implants and transcatheter heart valves. Topics include polymer basics, biocompatibility, biodegradation, and other tangentially related topics such as regulatory body approvals and intellectual property. Also listed as BIOE 208. Prerequisites: BIOE 10 and CHEM 13. (2 units)

109. Translational Development for Emerging Biomedical Devices

This course exposes the student to ongoing case-based interventional cardiology diagnostic and therapeutic biomedical device and clinical translational problems, where real world bioengineering innovative solutions are being envisioned and at times successfully being applied by startup teams of Bioengineers and Medical professionals. Bioengineering device design concepts and clinical translational development considerations are analyzed and case-based team project reports are assigned for final grading. Prerequisites: BIOE 10 and BIOE 21, BIOE 108 or BIOE 153 preferred. (4 units)

120. Experimental Methods in Bioengineering

This course will cover the principles of data representation, analysis, and experimental designs in bioreactors, biomaterials, and medical devices. Topics include error analyses, modeling, normality testing, hypothesis testing. Special emphasis will be placed on the interpretation of data from high-throughput assays used in “omics”/tissue engineering. Prerequisite: MATH 14. (4 units)

153. Biomaterials Science

Basic principles of material properties, biomaterials categories, biomaterials engineering concepts and selected applications and practical aspects are taught in this class. This course is a foundation for an entry level medical device engineer or bioengineering advanced degree. Prerequisite: CHEM 13. (4 units)

154. Introduction to Biomechanics

Engineering mechanics and applications in the analysis of human body movement, function, and injury. Review of issues related to designing devices for use in, or around, the human body including safety and biocompatibility. Prerequisites: BIOE 10, PHYS 33. (4 units)

155. Biological Transport Phenomena

The transport of mass, momentum, and energy are critical to the function of living systems and the design of medical devices. This course develops and applies scaling laws and the methods of continuum mechanics to biological transport phenomena over a range of length and time scales. Prerequisites: BIOE 10, PHYS 33, AMTH 106. (4 units)

157. Introduction to Biofuel Engineering

This course will cover the basic principles used to classify and evaluate biofuels in terms of thermodynamic and economic efficiencies as well as environmental impact for resource recovery. Special emphases will be placed on emerging applications namely microbial fuel cell technology and photo-bioreactors. Also listed as BIOE 257/ENGR 257. Prerequisites: BIOE 21 (or BIOL 1B), CHEM 13, PHYS 33. (2 units)

161. Bioinstrumentation

Transducers and biosensors from traditional to nanotechnology; bioelectronics and measurement system design; interface between biological system and instrumentation; data analysis; clinical safety. Laboratory component will include traditional clinical measurements and design and test of a measurement system with appropriate transducers. Prerequisites: BIOE 10, BIOE 21 (or BIOL 1B), ELEN 50. Co-requisite: BIOE 161L. (4 units)

161L. Bioinstrumentation Laboratory

Laboratory for BIOE 161. Co-requisite: BIOE 161. (1 unit)

162. Signals and Systems for Bioengineers

Origin and characteristics of bioelectric, bio-optical, and bioacoustic signals generated from biological systems. Behavior and response of biological systems to stimulation. Acquisition and interpretation of signals. Signal processing methods include FFT spectral analysis and time-frequency analysis. Laboratory component will include modeling of signal generation and analysis of signals such as electrocardiogram (ECG), electromyogram (EMG), and vocal sound pressure waveforms. Prerequisites: BIOE 10, COEN 45, ELEN 50, AMTH 106. Co-requisite: BIOE 162L. (4 units)

162L. Signals and Systems for Bioengineers Laboratory

Laboratory for BIOE 162. Co-requisite: BIOE 162. (1 unit)

163. Bio-Device Engineering

This course will instruct students with the fundamental principles of bio-device design, fabrication and biocompatibility, and let students experiment with the state-of-the-art bio-devices. Students will gain the hands-on experience with these bio-instruments which are also used in the field. Emphasis is given to the cutting-edge applications in biomedical diagnostics and pharmaceutical drug discovery and development, particularly detection and monitoring interaction, and activity of biomolecules, such as enzymes, receptors, antibody, nucleic acids, and bioanalytes. Prerequisites: BIOE 22 (or BIOL 1C) and CHEM 31. Co-requisite: BIOE 163L. (4 units)

163L. Bio-Device Engineering Laboratory

Laboratory for BIOE 163. Co-requisite: BIOE 163. (1 unit)

167. Medical Imaging Systems

Overview of medical imaging systems including sensors and electrical interfaces for date acquisition, mathematical models of the relationship of structural and physiological information to senor measurements, resolution and accuracy limits based on the acquisition system parameters, impact of the imaging system on the volume being imaged, data measured, and conversion process from electronic signals to image synthesis. Analysis of the specification and interaction of the functional units of imaging systems and the expected performance. Focus on MRI, CT, ultrasound, PET, and impedance imaging. Also listed as ELEN 167. Prerequisites: BIOE 162/ELEN 162 or ELEN 110 or MECH 142. (4 units)

168. Biophotonics and Bioimaging

This course focuses on the interactions of light with biological matter and includes topics on the absorption of light by biomolecules, cells, and tissues, and the emission of light from these molecules via fluorescence and phosphorescence. The course will cover the application of biophotonics in cell biology, biotechnology, and biomedical imaging. Also listed as BIOE 268. Prerequisites: BIOE 22 (or BIOL 1C) and CHEM 31, PHYS 33. Co-requisite: BIOE 168L. (2 units)

168L. Biophotonics and Bioimaging Laboratory

The lab will provide the hands-on experience for basic imaging and microscopy techniques as well as advanced techniques such as fiber optics and optical coherence tomography. Some of the experiments that will be conducted are: measuring the focal length of lenses and imaging using a single lens and a lens system, determining the magnification of optical systems (e.g. of a microscope), interference in young’s double slit and in Michelson configuration, diffraction, polarization and polarization rotation. Also listed as BIOE 268L. Co-requisite: BIOE 168. (1 unit)

171. Physiology and Anatomy for Engineers

Examines the structure and function of the human body and the mechanisms for maintaining homeostasis. The course will provide a molecular-level understanding of human anatomy and physiology in select organ systems. The course will include lectures, class discussions, case studies, computer simulations, field trips, lab exercises, and team projects. Prerequisite: BIOE 21 (or BIOL 1B). Co-requisite: BIOE 171L. (4 units)

171L. Physiology and Anatomy for Engineers Laboratory

Laboratory for BIOE 171. Co-requisite: BIOE 171. (1 unit)

172. Introduction to Tissue Engineering

Introduces the basic principles underlying the design and engineering of functional biological substitutes to restore tissue function. Cell sourcing, manipulation of cell fate, biomaterial properties and cell-material interactions, and specific biochemical and biophysical cues presented by the extracellular matrix will be discussed, as well as the current status and future possibilities in the development of biological substitutes for various tissue types. Prerequisite: BIOE 22 (or BIOL 1C). (4 units)

173. Advanced Topics in Tissue Engineering

Overview of the progress achieved in developing tools, technologies, and strategies for tissue engineering-based therapies for a variety of human diseases and disorders. Lectures will be complemented by a series of student-led discussion sessions and student team projects. Also listed as BIOE 273. Prerequisite: BIOE 172 (or with the consent of the instructor). (2 units)

174. Microfabrication and Microfluidics for Bioengineering Applications

Microfluidics uses principles from a broad range of disciplines including fluid mechanics, material science and optics for miniaturization, and automation of biochemical applications. This course will introduce the basic physical and engineering concepts which have practical importance in microfluidics and will allow better understanding of molecule and cell manipulation in the micro-domain. The course aims to introduce students to the state-of-art applications of various microfluidic techniques (e.g. mLSI, droplet and paper-based), in biological and biomedical research through lectures and discussion of current literature. Prerequisites: BIOE 10, BIOE 21 (or BIOL 1B). Co-requisite: BIOE 174L. (4 units)

174L. Microfabrication and Microfluidics for Bioengineering Applications Laboratory

Multilayer soft-lithography will be taught and integrated microfluidic chips will be built. Basic pressure driven microfluidic chip tests will be performed. A team design project that stresses interdisciplinary communication and problem solving is required in this course. Co-requisite: BIOE 174. (1 unit)

175. Biomolecular and Cellular Engineering I

This course will focus on solving problems encountered in the design and manufacturing of biopharmaceutical products, including antibiotics, antibodies, protein drugs, and molecular biosensors, with particular emphasis on the principle and application of protein engineering and reprogramming cellular metabolic networks. Prerequisites: BIOE 22 (or BIOL 1C) and CHEM 31, or equivalent knowledge and by instructor’s permission. BIOE 153 is recommended. Co-requisite: BIOE 175L. (4 units)

175L. Biomolecular and Cellular Engineering I Laboratory

Laboratory for BIOE 175. Co-requisite: BIOE 175. (1 unit)

176. Biomolecular and Cellular Engineering II

This course will focus on the principle of designing, manufacturing synthetic materials and their biomedical and pharmaceutical applications. Emphasis of this class will be given to chemically synthetic materials, such as polymers, and inorganic and organic compounds. Also listed as BIOE 226. Prerequisites: BIOE 22 (or BIOL 1C) and CHEM 31, or equivalent knowledge and by instructor’s permission. BIOE 171 and 175 are recommended. (4 units)

177A. Machine Learning: Fundamentals and Applications

This course covers fundamental methods that form the core of modern machine learning. Theoretical foundations for supervised and unsupervised learning, as well as neural networks will be introduced. Selected biomedical applications of machine learning will be presented. The co-requisite of this course will provide introductions to programming in Python and TensorFlow for algorithm implementation. Prerequisite: BIOE 120 or AMTH 108. Co-requisite: BIOE 177B. (2 units)

177B. Machine Learning: Algorithm Implementation

As the co-requisite of BIOE 177A, this course will focus on the algorithm implementation. Programming and building projects with TensorFlow, Keras, and NumPy will be discussed. (2 units)

179. Introduction to Neural Engineering

This course provides a foundation in the neural principles underlying existing and upcoming neurotechnologies. The goal is to understand the design criteria necessary for engineering interventions in neural structure and function with application to neurological diseases, disorders, and injuries. Topics include brain imaging and stimulation, neural implants, nanotechnologies, stem cell and tissue engineering. This course includes lectures, literature critiques, and design projects. Also listed as BIOE 275. Prerequisites: BIOE 21 (or BIOL 1B). BIOE 171 recommended. (2 units)

180. Clinical Trials: Design, Analysis and Ethical Issues

This course will cover the principles behind the logistics of design and analysis of clinical trials from statistical and ethical perspectives. Topics include methods used for quantification of treatment effect(s) and associated bias interpretation, crossover designs used in randomized clinical trials, and clinical equipoise. Also listed as BIOE 380. Prerequisites: BIOE 10, BIOE 120 (or AMTH 108), or with consent of the instructor. (4 units)

185. Physiology and Disease Biology

This course will provide a molecular-level understanding of physiology and disease biology, an overview of gastrointestinal diseases, and an introduction to medical devices used in diagnosis and treatment, as well as challenges in this field. This course will include lectures, class discussions, case studies, and team projects. Also listed as BIOE 285. Prerequisite: BIOE 21 (or BIOL 1B). BIOE 171 recommended. (2 units)

186. Introduction to Biotechnology

This course is designed to introduce basic and practical biotechniques to students with minimum training and background in biomolecular engineering. The basic principles and concepts of modern biotechniques will be illustrated and highlighted by studying real cases in lectures. Also listed as BIOE 286. Prerequisite: BIOE 22 or BIOL 1C. (2 units)

188. Co-op Education

Integration of classroom study and practical experience in a planned program designed to give students practical work experience related to their academic field of study and career objectives. The course alternates (or parallels) periods of classroom study with periods of training in industry or government. Satisfactory completion of the work assignment includes preparation of a summary report on co-op activities. P/NP grading. Prerequisites: Junior status and cumulative GPA ≥ 2.75. (2 units)

189. Work Experience and Co-op Technical Report

Credit is given for a technical report on a specific activity, such as a design or research activity, after completing a co-op work assignment. Letter grades will be based on the content and quality of the report. May be taken more than once. Prerequisites: BIOE 188, junior status, cumulative GPA ≥ 2.75, and approval of department co-op advisor. (2 units)

194. Design Project I

Specification of an engineering project, selected with the mutual agreement of the student and the project advisor. Complete initial design with sufficient detail to estimate the effectiveness of the project. Initial draft of the project report. Prerequisite: Senior standing. (2 units)

195. Design Project II

Continued design and construction of the project, system, or device. Second draft of the project report. Prerequisite: BIOE 194. (2 units)

196. Design Project III

Continued design and construction of the project, system, or device. Final project report. Prerequisite: BIOE 195. (2 units)

198. Internship

Directed internship in local bioengineering and biotech companies or research in off-campus programs under the guidance of research scientists or faculty advisors. Required to submit a professional research report. Open to upper-division students. (Variable units)

199. Supervised Independent Research

By arrangement. Faculty advisor required. (1–4 units)

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Administrative Assistant: Matthew Blanco

Santa Clara University
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