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Lu, Bill

Dr. Lu earned his MD and PhD from Fudan University (Shanghai) and University of Manitoba, Canada, where his research primarily focused on identifying novel enzymes through bioinformatics and molecular engineering. He developed expertise in areas including cancer research, metabolism and heart disease, protein engineering, stem cell research and regenerative medicine at University of California in San Francisco during his post-doc training. He also practiced medicine in New York and worked for a biotechnological company in Bay area developing molecular sensors and genome engineering technology before joining in the Department of Bioengineering at SCU.

Selected publications from peer-reviewed research articles and book chapters

  1. Johnston, S.R., Lu, B., Dowsett, M., Liang, X., Kaufmann, M., Scott, G.K., Osborne, C.K., and Benz, C.C. 1997. Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors. Cancer Res 57:3723-3727.
  2. Leygue, E., Dotzlaw, H., Lu, B., Glor, C., Watson, P.H., and Murphy, L.C. 1998. Estrogen receptor beta: mine is longer than yours? J Clin Endocrinol Metab 83:3754-3755.
  3. Liang, X., Lu, B., Scott, G.K., Chang, C., Baldwin, M., and Benz, C. 1998. Oxidant stress impaired DNA-binding of estrogen receptor from human breast cancer. Mol Cell Endocrinol 146:151-161.
  4. Lu, B., Leygue, E., Dotzlaw, H., Murphy, L.J., Murphy, L.C., and Watson, P.H. 1998. Estrogen receptor-beta mRNA variants in human and murine tissues. Mol Cell Endocrinol 138:199-203.
  5. Lu, B., Liang, X., Scott, G.K., Chang, C.H., Baldwin, M.A., Thomas, T., and Benz, C.C. 1998. Polyamine inhibition of estrogen receptor (ER) DNA-binding and ligand-binding functions. Breast Cancer Res Treat 48:243-257.
  6. Johnston, S.R., Lu, B., Scott, G.K., Kushner, P.J., Smith, I.E., Dowsett, M., and Benz, C.C. 1999. Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance. Clin Cancer Res 5:251-256.
  7. Lu, B., Dotzlaw, H., Leygue, E., Murphy, L.J., Watson, P.H., and Murphy, L.C. 1999. Estrogen receptor-alpha mRNA variants in murine and human tissues. Mol Cell Endocrinol 158:153-161.
  8. Lu, B., Leygue, E., Dotzlaw, H., Murphy, L.J., and Murphy, L.C. 2000. Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2. J Mol Endocrinol25:229-242.
  9. Murphy, L. C., E. Leygue, H. Dotzlaw, G.J. Huang, Lu B et al. (2000). Multiple facets of estrogen receptor in human breast cancer. Contemporary Endocrinology: Enocrine Oncology. S. P. Ethier. Totowa, Humana Press Inc.: 17-34.
  10. Emberley, E., Huang, G.J., Hamedani, M.K., Czosnek, A., Ali, D., Grolla, A., Lu, B., Watson, P.H., Murphy, L.C., and Leygue, E. 2003. Identification of new human coding steroid receptor RNA activator isoforms. Biochem Biophys Res Commun 301:509-515.
  11. Jiang, Y.J., Lu, B., Choy, P.C., and Hatch, G.M. 2003. Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFalpha, LPS and M-CSF in human monocytes and macrophages. Mol Cell Biochem 246:31-38.
  12. Jiang, Y.J., Xu, T.R., Lu, B., Mymin, D., Kroeger, E.A., Dembinski, T., Yang, X., Hatch, G.M., and Choy, P.C. 2003. Cyclooxygenase expression is elevated in retinoic acid-differentiated U937 cells.Biochim Biophys Acta 1633:51-60.
  13. Peng, B., Lu, B., Leygue, E., and Murphy, L.C. 2003. Putative functional characteristics of human estrogen receptor-beta isoforms. J Mol Endocrinol 30:13-29.
  14. Jiang, Y.J., Lu, B., Xu, F.Y., Gartshore, J., Taylor, W.A., Halayko, A.J., Gonzalez, F.J., Takasaki, J., Choy, P.C., and Hatch, G.M. 2004. Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. J Lipid Res 45:244-252.
  15. Lu, B., Jiang, Y.J., and Choy, P.C. 2004. 17-Beta estradiol enhances prostaglandin E2 production in human U937-derived macrophages. Mol Cell Biochem 262:101-110.
  16. Lu, B., Kelher, M.R., Lee, D.P., Lewin, T.M., Coleman, R.A., Choy, P.C., and Hatch, G.M. 2004. Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissues. Biochem Cell Biol 82:569-576.
  17. Lu, B., Jiang, Y.J., Man, M.Q., Brown, B., Elias, P.M., and Feingold, K.R. 2005. Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis. J Lipid Res46:2448-57.
  18. Lu, B., Jiang, Y.J., Zhou, Y., Xu, F.Y., Hatch, G.M., and Choy, P.C. 2005. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARa in murine heart. Biochem J 385:469-477.
  19. Webster, J., Jiang, J.Y., Lu, B., Xu, F.Y., Taylor, W.A., Mymin, M., Zhang, M., Minuk, G.Y., and Hatch, G.M. 2005. On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration. Biochem J 386:137-143.
  20. Jiang, Y.J., Lu, B., Kim, P., Elias, P.M., and Feingold, K.R. 2006. Regulation of ABCA1 expression in human keratinocytes and murine epidermis. J Lipid Res 47:2248-2258.
  21. Lu, B., Moser, A.H., Shigenaga, J.K., Feingold, K.R., and Grunfeld, C. 2006. Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response. J Lipid Res 47:2179-2190.
  22. Lu, B., Xu, F.Y., Jiang, Y.J., Choy, P.C., Hatch, G.M., Grunfeld, C., and Feingold, K.R. 2006. Cloning and characterization of a cDNA encoding human cardiolipin synthase. J Lipid Res 47:1140-1145.
  23. Lu, B., Sims, P.J., Wiedmer, T., Moser, A.H., Shigenaga, J.K., Grunfeld, C., and Feingold, K.R. 2007. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Biochim Biophys Acta 1771:1177-1185.
  24. Van, Q., Liu, J., Lu, B., Feingold, K.R., Shi, Y., Lee, R.M., and Hatch, G.M. 2007. Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells.Biochem J 401:103-109.
  25. Jiang, Y.J., Lu, B., Kim, P., Paragh, G., Schmitz, G., Elias, P.M., and Feingold, K.R. 2008. PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. J Invest Dermatol128:104-109.
  26. Lu, B., Lu, Y., Moser, A.H., Shigenaga, J.K., Grunfeld, C., and Feingold, K.R. 2008. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 295:E1502-1509.
  27. Jiang, Y.J., Barish, G., Lu, B., Evans, R.M., Crumrine, D., Schmuth, M., Elias, P.M., and Feingold, K.R. 2009. PPARdelta activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. J Invest Dermatol 130:511-519.
  28. Jiang, Y.J., Lu, B., Crumrine, D., Elias, P.M., and Feingold, K.R. 2009. IL-6 Stimulates but is not essential for stratum corneum formation and permeability barrier development during gestation.Exp Dermatol 19(8):e31-6.
  29. Jiang, Y.J., Lu, B, Crumrine, D., Man, M.Q., Elias, P.M., and Feingold, K.R. 2009. IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development. J Dermatol Sci 54:88-98.
  30. Jiang, Y.J., Uchida, Y., Lu, B, Kim, P., Mao, C., Akiyama, M., Elias, P.M., Holleran, W.M., Grunfeld, C., and Feingold, K.R. 2009. Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes. J Biol Chem 284:18942-18952.
  31. Lu, B, Moser, A., Shigenaga, J.K., Grunfeld, C., and Feingold, K.R. 2010. The acute phase response stimulates the expression of angiopoietin like protein 4. Biochem Biophys Res Commun391:1737-41.
  32. Jiang YJ, Barish G, Lu B, Evans RM, Crumrine D, Schmuth M, Elias PM, Feingold KR. (2010) PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. J Invest Dermatol 130(2):511-9.
  33. Jiang YJ, Lu B, Tarling E, Kim P, Man M, Edwards PA, Elias PM, Feingold KR. (2010) Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res 51:3185-95.
  34. Lu B, Jiang YJ, Kim P, Moser A, Elias PM, Grunfeld C, Feingold KR. (2010) Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis. J Lipid Res51(11):3207-16.
  35. Lu B, Xu FY, Taylor WA, Feingold KR, Hatch GM. (2011) Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in Mammalian lipopolysaccharide models of inflammation. Inflammation 34(4):247-54.
  36. Uhde-Stone C, Huang J, Lu B. (2012) A robust dual reporter system to visualize and quantify gene expression mediated by transcription activator-like effectors. Biol Proced Online 14(1):8.
  37. Uhde-Stone C, Gor NL, Chin T, Huang J, Lu B. (2013). A do-it-yourself protocol for simple TALE assembly. Biol Proced Online 15(1):3.
  38. Uhde-Stone C, Cheung E, Lu B. (2014). TALE activators regulate gene expression in a position- and strand-dependent manner in mammalian cells." Biochem Biophys Res Commun 443(4):1189-94.
  39. Afshari A, Uhde-Stone C, Lu B. (2014). Live visualization and quantification of pathway signaling with dual fluorescent and bioluminescent reporters. Biochem Biophys Res Commun 448(3):281-6.
  40. Uhde-Stone C, Sarkar N, Antes T, Otoc N, Kim Y, Jiang YJ, Lu B. (2014). A TALEN-based strategy for efficient bi-allelic miRNA ablation in human cells. RNA 20(6):948-55.
  41. Afshari A, Uhde-Stone C, Lu B (2015). A cooled CCD camera-based protocol provides an effective solution for in vitro monitoring of luciferase. Biochem Biophys Res Commun 458(3):543-8.
Bill Lu, Bioengineering
Assistant Professor, Department of Bioengineering
Email: blu2@scu.edu
  • Delivering the Goods

    Bioengineering undergraduate Grace Ling and Assistant Professor Bill Lu, M.D., Ph.D., are testing a new method of gene therapy that safely delivers DNA to mutated cells without using viruses for transport, as is the current norm.